Cambridge scientists have developed and tested a new drug in mice that has the potential to reduce damage to the brain when blood flow is restored following a stroke.

As many as one in four people will have a stroke during their lifetime. This is when a blood clot prevents oxygen from reaching a part of the brain.

Multidrug resistant bacteria kill five million people each year, with newly resistant germs emerging faster than scientists can develop treatments.

Now, researchers have developed a platform that identifies drug resistance genes already circulating in the environment before they emerge in the clinic and directly couples this information to the design of resistance-evasive antibiotics.

A healthy diet can slow down the accumulation of chronic diseases in older adults, while inflammatory diets accelerate it. This is shown by a new study from Karolinska Institutet published in Nature Aging.

Researchers have investigated how four different diets affect the accumulation of chronic diseases in older adults. Three of the diets studied were healthy and focused on the intake of vegetables, fruit, whole grains, nuts, legumes, unsaturated fats and reduced intake of sweets, red meat, processed meat and butter/margarine.

A landmark study has revealed that autoantibodies - immune proteins traditionally associated with autoimmune disease - may profoundly influence how cancer patients respond to immunotherapy.

The study, published in Nature, offers a potential breakthrough in solving one of modern-day oncology’s most frustrating mysteries: why checkpoint inhibitors work for some patients but not others - and how we can extend their benefits to more people.

While current treatments for schizophrenia - a mental illness affecting 1% of the world’s population - can reduce certain symptoms, they have little effect on the cognitive deficits affecting the daily life of patients.

Scientists at the Institute of Functional Genomics (CNRS/Inserm/Université de Montpellier) have just designed a nanobody made from llama antibodies that can specifically activate a glutamate receptor involved in regulating neural activity.

An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to "wake up" the immune system against cancer.

Published in Nature Biomedical Engineering, the University of Florida study showed that like a one-two punch, pairing the test vaccine with common anticancer drugs called immune checkpoint inhibitors triggered a strong antitumor response.

Chemists have developed a novel way to generate a variety of highly useful chemical building blocks by harnessing metal carbenes, suggests new research.

Typically used in chemical reactions essential for drug synthesis and materials development, carbenes are short-lived, highly reactive carbon atoms.