Research

Official COVID-19 deaths underestimate the full impact of the pandemic

According to a study by Charité - Universitätsmedizin Berlin, the northern Italian city of Nembro recorded more deaths during March 2020 than between January and December 2019. However, only approximately half of all deaths recorded this spring were classified as confirmed COVID-19 deaths. The study shows that the health impacts of the COVID-19 pandemic may go far beyond official COVID-19 death counts.

Local climate unlikely to drive the early COVID-19 pandemic

Local variations in climate are not likely to dominate the first wave of the COVID-19 pandemic, according to a Princeton University study published May 18 in the journal Science.

The researchers found that the vast number of people still vulnerable to the strain of coronavirus causing the pandemic - SARS-CoV-2 - and the speed at which the pathogen spreads means that climate conditions are only likely to make a dent in the current rate of infection.

Researchers urge clinical trial of blood pressure drug to prevent complication of COVID-19

Researchers in the Ludwig Center at the Johns Hopkins Kimmel Cancer Center report they have identified a drug treatment that could - if given early enough - potentially reduce the risk of death from the most serious complication of Coronavirus disease 2019 (COVID-19), also known as SARS-CoV-2 infection.

Antibody neutralizes SARS and COVID-19 coronaviruses

An antibody first identified in a blood sample from a patient who recovered from Severe Acute Respiratory Syndrome in 2003 inhibits related coronaviruses, including the cause of COVID-19.

The antibody, called S309, is now on a fast-track development and testing path at Vir Biotechnology in the next step toward possible clinical trials.

Early indicators of vaccine efficacy

Ludwig-Maximilians-Universität (LMU) in Munich researchers have shown that a specific class of immune cells in the blood induced by vaccination is an earlier indicator of vaccine efficacy than conventional tests for neutralizing antibodies. The current coronavirus pandemic, together with episodic outbreaks of infections caused by other pathogenic viruses, represent a growing threat to societies around the world, especially when effective vaccines are either lacking altogether or are in short supply.

Arthritis drug may improve respiratory function in some patients with severe COVID-19

A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19). The eight patients also had a condition called secondary hemophagocytic lymphohistiocytosis (sHLH), which is characterized by overactivation of the immune system and organ failure.

Frankfurt researchers discover potential targets for COVID-19 therapy

A team of biochemists and virologists at Goethe University and the Frankfurt University Hospital were able to observe how human cells change upon infection with SARS-CoV-2, the virus causing COVID-19 in people. The scientists tested a series of compounds in laboratory models and found some which slowed down or stopped virus reproduction. These results now enable the search for an active substance to be narrowed down to a small number of already approved drugs.

Official COVID-19 deaths underestimate the full impact of the pandemic

Local climate unlikely to drive the early COVID-19 pandemic

Researchers urge clinical trial of blood pressure drug to prevent complication of COVID-19

Antibody neutralizes SARS and COVID-19 coronaviruses

Early indicators of vaccine efficacy

Arthritis drug may improve respiratory function in some patients with severe COVID-19

Frankfurt researchers discover potential targets for COVID-19 therapy

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