Research

A nasal spray protects against coronavirus infection - Effective also against recent immune-evasive variants

Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of the SARS-CoV-2 virus. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both the transmission and spread of the virus.

In laboratory animal studies, a molecule known as TriSb92, developed by researchers at the University of Helsinki, has been confirmed as affording effective protection against coronavirus infection.

'Biohybrid' device could restore function in paralysed limbs

Researchers have developed a new type of neural implant that could restore limb function to amputees and others who have lost the use of their arms or legs.

In a study carried out in rats, researchers from the University of Cambridge used the device to improve the connection between the brain and paralysed limbs. The device combines flexible electronics and human stem cells - the body's 'reprogrammable' master cells - to better integrate with the nerve and drive limb function.

Scientists use tardigrade proteins for human health breakthrough

University of Wyoming researchers' study of how microscopic creatures called tardigrades survive extreme conditions has led to a major breakthrough that could eventually make life-saving treatments available to people where refrigeration isn’t possible.

Thomas Boothby, an assistant professor of molecular biology, and colleagues have shown that natural and engineered versions of tardigrade proteins can be used to

DNA treatment could delay paralysis that strikes nearly all patients with ALS

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell. In turn, this triggers the loss of stathmin-2, a protein crucial to regeneration of neurons and the maintenance of their connections to muscle fibers, essential to contraction and movement.

Scientists reveal a potential new approach to treating liver cancer

Scientists at the National Institutes of Health and Massachusetts General Hospital in Boston have uncovered a potential new approach against liver cancer that could lead to the development of a new class of anticancer drugs. In a series of experiments in cells and mice, researchers found that an enzyme produced in liver cancer cells could

Normalizing tumor blood vessels may improve immunotherapy against brain cancer

A type of immune therapy called chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of multiple types of blood cancers but has shown limited efficacy against glioblastoma - the deadliest type of primary brain cancer - and other solid tumors.

Engineered bacteria find tumors, then alert the authorities

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host’s own immune cells to the cancer to destroy it. The new work, published today in Science Advances, marks a major step forward in efforts to enlist non-pathogenic bacteria to combat cancer.

A nasal spray protects against coronavirus infection - Effective also against recent immune-evasive variants

'Biohybrid' device could restore function in paralysed limbs

Scientists use tardigrade proteins for human health breakthrough

DNA treatment could delay paralysis that strikes nearly all patients with ALS

Scientists reveal a potential new approach to treating liver cancer

Normalizing tumor blood vessels may improve immunotherapy against brain cancer

Engineered bacteria find tumors, then alert the authorities

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