Vaccines trigger a notably rapid response in the stromal cells of draining lymph nodes within the first hours after administration. Researchers at the University of Turku and the InFLAMES Flagship in Finland also discovered that the stromal alterations prime the lymph node landscape for the subsequent steps of vaccine-induced immune responses.

Lymph nodes are a key part of the human immune system, whose primary function is to combat infections.

A new study from Moffitt Cancer Center may offer a breakthrough for patients with advanced melanoma who don’t respond to current immunotherapy treatments. The research, published in the Journal for ImmunoTherapy of Cancer, found that adding a third immune-targeting drug to existing therapies helped shrink tumors in lab models of treatment-resistant melanoma.

Immunotherapy works by activating the body’s own immune system to attack cancer.

The mitochondria may be the powerhouse of the cell, but mounting evidence suggests this organelle is also a driving force behind cancer. Now, new evidence points to the mitochondrial metabolite glutathione, highlighting its central role in helping breast cancer cells break away from the primary tumor, travel through the body, and take root in other tissues.

The findings are among the first to link a specific mitochondrial metabolite to metastasis, with strong implications for the study of cancer at the cellular level.

Patients in a Phase I/II clinical trial conducted by UMass Chan Medical School of a dual vector gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases, exhibited a biochemical correction of the disease with minimal adverse reactions.

"Biochemically it worked," said study investigator Heather Gray-Edwards, DVM, PhD, assistant professor of genetic & cellular medicine at UMass Chan.

New research from the Charles Perkins Centre at the University of Sydney has uncovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing dangerous blood clots, potentially paving the way for future treatments that reduce their cardiovascular risk.

The study, led by Associate Professor Freda Passam from the Central Clinical School and Associate Professor Mark Larance from the School of Medical Sciences, was published in the Journal of Clinical Investigation.

ADAMTS2, a member of the ADAMTS zinc metalloproteinase family, is widely recognized for its pivotal role as a procollagen I N-proteinase. This enzyme plays a crucial part in the maturation of fibrillar collagens, which are essential for maintaining the structural integrity of connective tissues. Beyond its traditional role, recent discoveries have revealed that ADAMTS2 is involved in a diverse range of biological processes that extend well beyond collagen maturation.

The pharmaceutical industry stands at a transformative crossroads as artificial intelligence reshapes the landscape of drug development. In a Correspondence published in the KeAi journal Current Molecular Pharmacology, a group of researchers from China illuminate how large language models (LLMs) - the sophisticated AI systems powering advanced chatbots - are delivering unprecedented breakthroughs across the entire drug discovery pipeline.