Latest Internet Technology for the Replacement of Animal Experiments

Developed in close cooperation between Transinsight, Dresden, and the German Federal Institute for Risk Assessment, Berlin, the knowledge-based semantic search engine www.Go3R.org is now available online. It enables information transparency for the prevention of animal testing.

In only four months development time, Transinsight from Dresden, Germany, succeeded in making available online Go3R, the worldwide first knowledge-based search engine for alternative methods to animal experiments. Via www.Go3R.org, scientists from all over the world can take advantage of the benefits of semantic searches for the area of alternative methods in accordance with the 3Rs principle. The Search engine can from now on used as Beta version.

The so-called 3Rs principle developed by Russell and Burch in 1959 stands for Replacement, Reduction and Refinement. It describes scientific methods that can either replace animal experiments, or reduce animal numbers or refine the suffering of the animals during the procedures. In the European Union, compliance with the 3Rs principle is legally required. In accordance with the EU Laboratory Animal Directive, just as with the German Animal Welfare Act, animal experiments may only be performed if the scientific goal pursued cannot be achieved by any other means, i.e. in totally non-animal procedures, or in methods using fewer animals or entailing less animal suffering.

In practice, however, this legal requirement oftentimes is not met, because the scientists and the responsible authorities are unaware of 3Rs alternatives that would exist to the respective foreseen animal experiment. Queries for alternative methods are time consuming and cumbersome, and this situation has possibly even become worse in the era of the internet. Additionally, at the end of a search, it remains unclear whether all relevant information sought for was indeed retrieved. This is where the search engine Go3R sets in.

"With Go3R, search retrievals for alternatives to animal experiments become transparent and they are available without delay. Time savings of 90 percent and more are already possible with the first prototype of the search engine", explains Dr. Michael R. Alvers, CEO and Co-Founder of Transinsight. "With our information technology Go3R, we are pleased to be able to present scientists with a tool that enables them to determine the indispensability of animal experiments more reliably. Go3R promotes the 3Rs principle. In the medium term, this will lead to a significant reduction of animal experiments. Achieving a world with less and less animal experiments is the worthwhile goal that Transinsight is happy to make a contribution to with all its might", says Alvers.

Go3R was developed in cooperation with scientists from the Technical University Dresden and the National German Centre for Documentation and Evaluation of Alternatives to Animal Experiments (ZEBET) at the German Federal Institute for Risk Assessment in Berlin. With its expertise in the area of alternative methods, ZEBET has provided the specialist know how for the search machine.

"Already today, Germany is leading in the area of development of alternative methods. The new search engine will make a contribution further to promote Germany's international reputation. The combination of ZEBET's expertise - acquired over decades - with latest semantic search technologies will lead to a new generation of science as regards avoidance of animal experiments", declares Professor Dr. Horst Spielmann, international scientist of excellence in the area of alternative methods and for many years, Head of ZEBET.

In a next step, the search engine www.Go3R.org is now being extended to become a community platform enabling global cooperation without language barriers. It is the goal of the investment to achieve maximum availability of information with simultaneous transparency for scientists and researchers all over the world. The service is available free of charge.

Related news articles:

About Transinsight
Founded in 2005, Transinsight is focused on software solutions for the life sciences providing products for knowledge-based technologies. The flagship product, www.GoPubMed.com, a well established biomedical search engine, is the first knowledge-based search engine for the Life Sciences on the Internet. Transinsight is headquartered in one of the leading German biotech incubators, the BioInnovationCenter Dresden BIOZ, where science and business work under one roof. Transinsight works in close collaboration with the Technical University Dresden.

For more information about Transinsight, visit www.transinsight.com.

Most Popular Now

Pfizer's elranatamab granted FDA Breakthrough Ther…

Pfizer Inc. (NYSE:PFE) announced its investigational cancer immunotherapy, elranatamab, received Breakthrough Therapy Designation from the U.S. Food and Drug Administrati...

Salvat Laboratories announces submission of New Dr…

Salvat Laboratories announced that it has submitted a New Drug Application (NDA) to the FDA for the approval of the first ocular corticosteroid formulated in a nanoemulsi...

Bayer with continued strong performance

The Bayer Group maintained its strong business performance across all three divisions in the third quarter. "Despite rising inflation and global supply chain problems, we...

Vividion Therapeutics names Jenna Goldberg as Chie…

Vividion Therapeutics, Inc., a biopharmaceutical company utilizing novel discovery technologies to unlock high value, traditionally undruggable targets with precision the...

New insights on antibody responses to Omicron vari…

Knowing how well vaccination against one SARS-CoV-2 strain (with or without previous infection) counteracts infection with a different strain is a critical research quest...

Pfizer and BioNTech receive positive CHMP opinion …

Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) announced a booster dose of their Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine (COMIRNATY® Original/Omicron ...

Sugar molecules as a target in cancer therapy

Cancer cells use sugar molecules on their surface to disable attacks by the body's immune system. Researchers at the University of Basel now report on how this mechanism ...

COVID vaccination improves effectiveness of cancer…

Patients with nasopharyngeal cancer are often treated with drugs that activate their immune system against the tumor. Until now, it was feared that vaccination against Co...

Making melanoma immortal: Pitt scientists discover…

Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality. I...

New drug shows promise for fighting both COVID-19 …

While vaccination can provide life-saving protection against COVID-19, scientists are still searching for ways to treat severe infections, including in people who cannot ...

Study reveals vaccine confidence declined consider…

A new study suggests that, despite the success of the COVID-19 vaccination campaigns, vaccine confidence has declined significantly since the start of the pandemic. Re...

Sanofi and GSK's next-generation COVID-19 booster …

After the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for VidPrevtyn® Beta, the vaccine was approved by t...