New light on medicinal benefits of plants

Scientists are about to make publicly available all the data they have so far on the genetic blueprint of medicinal plants and what beneficial properties are encoded by the genes identified.

The resources follow a $6 million initiative to study how plant genes contribute to producing various chemical compounds, some of which are medicinally important.

"Our major goal has been to capture the genetic blueprints of medicinal plants for the advancement of drug discovery and development," said Joe Chappell, professor of plant biochemistry in the University of Kentucky College of Agriculture and coordinator for the Medicinal Plant Consortium (MPC).

Project partner Dr Sarah O'Connor at the John Innes Centre will now work with her research group towards the first full genetic sequence of a medicinal plant and will also experiment with combining beneficial properties from different plants to create the first new-to-nature compounds derived from plants. A priority focus will be compounds with anticancer activity.

"Fewer and fewer new drugs have been successfully making it to the marketplace over the last 10 years, in large part because of a reliance on chemical synthesis for making new chemicals," said Chappell.

"Somehow in our fast-track lives, we forgot to take advantage of the lessons provided by Mother Nature. That is all changing now with the recognition that two-thirds of all currently prescribed drugs can be traced back to natural sources and the development of resources such as those in the MPC to facilitate new drug discovery activities."

Some well-known medicines have come from plants. The once ubiquitous foxglove gives us the cardiac muscle stimulant digoxin. The periwinkle plant offers a source for the widely used chemotherapy drugs vincristine and vinblastine. These and many other medicinal plants, often commonly found in household gardens and flower boxes, harbour a wealth of compounds ripe for medicinal applications.

"Just as the sensory properties of plants interact with and trigger your sense of smell, plants' natural compounds can target and cause a reaction within your body. This gives them tremendous pharmaceutical potential," said Chappell.

During this two-year project researchers set out to develop a collection of data that would aid in understanding how plants make chemicals, a process called biosynthesis. This knowledge ultimately could make it possible to engineer plants to produce larger quantities of medicinally useful compounds as well as different versions with other therapeutic potential.

To develop the resources, the researchers studied the genes and chemical profiles of 14 plants known for medicinal properties or compounds with biological activity. These included plants such as foxglove, ginseng, and periwinkle. The findings will help researchers discover how nature's chemical diversity is created and enable them to uncover new drug candidates or increase the efficacy of existing ones.

"The current understanding of molecules and genes involved in the formation of beneficial compounds is very incomplete," said O'Connor, who is also a lecturer in chemical sciences at University of East Anglia.

"However, the ability to conduct genome-wide studies of model plant species has resulted in an explosive increase in our knowledge of and capacity to understand how genes control biological processes and chemical composition".

The MPC project includes participants from the University of Kentucky, Michigan State University, Iowa State University, the University of Mississippi, Purdue University, Texas A&M University, Massachusetts Institute of Technology, and the John Innes Centre in Norwich. The researchers represent a broad spectrum of expertise from plant biology and systematics to analytical chemistry, genetics and molecular biology, and drug development from natural products.

Most Popular Now

AstraZeneca takes next steps towards broad and equ…

AstraZeneca has taken the next steps in its commitment to broad and equitable global access to the University of Oxford’s COVID-19 vaccine, following landmark agreements ...

Johnson & Johnson announces acceleration of it…

Johnson & Johnson (NYSE: JNJ) (the Company) today announced that through its Janssen Pharmaceutical Companies (Janssen) it has accelerated the initiation of the Phase 1/2...

Low-cost dexamethasone reduces death by up to one …

In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for C...

Sanofi invests to make France its world class cent…

Sanofi detailed plans on how the Company will make significant investments in France to increase its vaccines research and production capacities, and contribute in respon...

Calquence showed promising clinical improvement in…

Results published in Science Immunology showed that Calquence (acalabrutinib), a Bruton’s tyrosine kinase (BTK) inhibitor, reduced markers of inflammation and improved cl...

Super-potent human antibodies protect against COVI…

A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus ...

New consortium EUbOPEN will provide tools to unloc…

Almost twenty years after deciphering the human genome, our understanding of human disease is still far from complete. One of the most powerful and versatile tools to bet...

AstraZeneca to supply Europe with up to 400 millio…

AstraZeneca has reached an agreement with Europe's Inclusive Vaccines Alliance (IVA), spearheaded by Germany, France, Italy and the Netherlands, to supply up to 400 milli...

Up to 45 percent of SARS-CoV-2 infections may be a…

An extraordinary percentage of people infected by the virus behind the ongoing deadly COVID-19 pandemic never show symptoms of the disease, according to the results of a ...

Researchers identify potent antibody cocktail to t…

Researchers at the University of Maryland School of Medicine (UMSOM) evaluated several human antibodies to determine the most potent combination to be mixed in a cocktail...

Gilead announces results from Phase 3 Trial of rem…

Gilead Sciences, Inc. (Nasdaq: GILD) announced topline results from the Phase 3 SIMPLE trial in hospitalized patients with moderate COVID-19 pneumonia. This open-label st...

Mayo finds convalescent plasma safe for diverse pa…

Mayo Clinic researchers and collaborators have found investigational convalescent plasma to be safe following transfusion in a diverse group of 20,000 patients. The findi...