A University of Missouri researcher has created a computer program that can unravel the mysteries of how proteins work together - giving scientists valuable insights to better prevent, diagnose and treat cancer and other diseases.

Jianlin "Jack" Cheng from Mizzou's College of Engineering and his student, Nabin Giri, have developed a tool called Cryo2Struct that uses artificial intelligence (AI) to build the three-dimensional atomic structure of large protein complexes, work recently published in Nature Communications.

Women in the UK, and elsewhere, are still missing out on vital treatment for their No 1 killer - cardiovascular disease - despite significant progress in the medical management of heart disease and stroke, concludes a consensus statement published online in the journal Heart.

They continue to be underdiagnosed, undertreated, and underrepresented in clinical trials in all areas of cardiovascular disease, says the statement.

Researchers from the Food Packaging Forum identify and discuss nearly 200 potential breast carcinogens that have been detected in food contact materials (FCMs) on the market. Many nations have food contact material legislation intended to protect citizens from hazardous chemicals, often specifically by regulating genotoxic carcinogens. As cancer is one of the few health endpoints specifically targeted in FCM regulations and testing, carcinogenic chemicals in food packaging and other food contact materials and articles should not be commonplace.

Some triptans are a more effective treatment for acute migraines than newer, more expensive drugs, finds an analysis of the latest evidence published by The BMJ.

Triptans work by narrowing blood vessels in the brain and preventing the release of chemicals that cause pain and inflammation.

The findings show that four triptans - eletriptan, rizatriptan, sumatriptan, and zolmitriptan - were better at relieving migraine pain than the recently marketed and more expensive drugs lasmiditan, rimegepant, and ubrogepant, which were comparable to paracetamol and most anti-inflammatory painkillers (NSAIDs).

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets. A serious concern, off-target drug binding is a significant cause of adverse events in patients, with the potential to even cause death. Analysis of antibody off-target binding across different phases of clinical development suggests this to be a major cause of drug attrition. Early specificity testing could improve drug approvals and patient safety.

More than 39 million people around the world could die from antibiotic-resistant infections over the next 25 years, according to a study published in The Lancet.

The new study by the Global Research on Antimicrobial Resistance (GRAM) Project is the first global analysis of antimicrobial resistance (AMR) trends over time.

It reveals that more than one million people died each year as a result of AMR between 1990 and 2021.

Cancer has been described as "a wound that does not heal," implying that the immune system is unable to wipe out invading tumor cells. A new discovery confirms that a key molecule can reprogram immune cells that normally protect against infection and cancer, turning them into bad guys that promote cancer growth.

Studying the behavior of these "pro-tumor" immune cells is important because they could be targets for therapies that block their harmful activity, said Minsoo Kim, PhD, corresponding author of the study and a research leader at the Wilmot Cancer Institute.