The hematopoietic cell transplant team in Osaka Metropolitan University Graduate School of Medicine has developed a novel strategy using a new drug combination, which demonstrated significant anti-cancer effect with mild toxicity for relapsed/refractory AML patients. In addition, the detailed immunological study showed how a new drug induced the enhancement of anti-cancer activity via alterations of immune cells.
In correspondence published in the Nature-affiliated Blood Cancer Journal, the researchers report on their clinical observational study using venetoclax in combination with azacitidine as the treatment for 12 patients with AML who relapsed after allogeneic hematopoietic cell transplantation.
Venetoclax is an oral medication developed by AbbVie and Roche that was approved by the U.S. Food and Drug Administration in October 2020 for AML. It has shown promising results for older patients with untreated AML in promoting the death of cancer cells by inhibiting a regulator protein known as BCL-2.
The OMU researchers' study showed markedly better survival rates after one year for the venetoclax combination therapy group than a control group of 61 patients, at 66.7% to 27.3%. They also showed in the immunological study that the alterations of immune cells induced by venetoclax had enhanced the anti-tumor activity.
"This study demonstrates that novel therapy can improve the prognosis of relapsed/refractory acute myeloid leukemia through both clinical and basic approaches. This therapy can be applied to more patients because of the reduction of the treatment burden," proclaimed Dr. Mitsutaka Nishimoto, the corresponding author. "We hope this will lead to the development of safer, more effective treatments."
Nagasaki J, Nishimoto M, Koh H, Okamura H, Nakamae M, Sakatoku K, Ido K, Kuno M, Makuuchi Y, Takakuwa T, Nakashima Y, Hino M, Nakamae H.
T cells with high BCL-2 expression induced by venetoclax impact anti-leukemic immunity "graft-versus-leukemia effects".
Blood Cancer J. 2024 May 14;14(1):79. doi: 10.1038/s41408-024-01064-0