Immunological memory after cured Sars-CoV-2 infection

Until now, it was unclear whether a survived SARS-CoV-2 infection or COVID-19 leads to a persistent immunological memory and thus can protect against a new infection. Several studies had shown that SARS-CoV-2 specific antibodies are only detectable for a few months in many people who have survived COVID-19 and may therefore only provide temporary protection against re-infection. A research team at the Medical Center - University of Freiburg led by Dr. Maike Hofmann, Dr. Christoph Neumann-Haefelin and Prof. Dr. Robert Thimme has now been able to show: after recovery from SARS-CoV-2 infection, immune cells are formed which remain in the body and could mediate a rapid immune response in case of re-infection. The Freiburg study was published in the online edition of the renowned scientific journal Nature Medicine on November 12, 2020.

"These so-called memory T-cells after SARS-CoV-2 infection look similar to those after a real flu. We are therefore confident that the majority of people who have survived SARS-CoV-2 infection have some protection against re-infection with SARS-CoV-2," explains Dr. Hofmann, a scientist at the Department of Medicine II at the Medical Center - University of Freiburg.

Professor Thimme, Medical Director of the Department of Medicine II, emphasizes how important a good translational research environment such as that at the Medical Center - University of Freiburg is in the current situation: "In order to obtain robust research results within a few months, close networking between clinic and science at the highest level is a basic requirement: On the one hand, patients with COVID-19 are treated on our wards and continue to be cared for in a special outpatient clinic even after the infection has healed. On the other hand, our clinic has great expertise in the analysis of immune cells in viral infections such as hepatitis B and C."

The Medical Center - University of Freiburg is not involved in the development of vaccines against SARS-CoV-2. However, Dr. Neumann-Haefelin, Head of the Gerok Liver Center at the University Hospital Freiburg, is optimistic: "Our results suggest that immunity against SARS-CoV-2 can be achieved after an infection. Similarly, vaccines currently being tested in trials could provide significant protection against SARS-CoV-2".

"The deciphering of complex immune responses has long been part of the research focus of the University and the Medical Center - University of Freiburg. Thanks to the high scientific quality onsite, we can now make an important contribution to the corona pandemic," says Prof. Dr. Norbert Südkamp, Dean of the Medical Faculty at the Albert-Ludwigs-University of Freiburg.

Isabel Schulien, Janine Kemming, Valerie Oberhardt, Katharina Wild, Lea M Seidel, Saskia Killmer, Sagar, Franziska Daul, Marilyn Salvat Lago, Annegrit Decker, Hendrik Luxenburger, Benedikt Binder, Dominik Bettinger, Oezlem Sogukpinar, Siegbert Rieg, Marcus Panning, Daniela Huzly, Martin Schwemmle, Georg Kochs, Cornelius F Waller, Alexandra Nieters, Daniel Duerschmied, Florian Emmerich, Henrik E Mei, Axel Ronald Schulz, Sian Llewellyn-Lacey, David A Price, Tobias Boettler, Bertram Bengsch, Robert Thimme, Maike Hofmann, Christoph Neumann-Haefelin.
Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells.
Nature Medicine, 2020. doi: 10.1038/s41591-020-01143-2

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