Interactions discovered in cells insulating nerve pathways

Schwann cells form a protective sheath around nerve fibres and ensure that nerve impulses are transmitted rapidly. If these cells are missing or damaged, severe neurological diseases may occur as a result. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in demonstrating a complex interaction within Schwann cells which plays an important role for correct cell maturation.

Insulation and nutrients

For years, Dr. Franziska Fröb and Dr. Michael Wegner have devoted most of their time to researching one particular type of cell in the human body: Schwann cells. Similarly to insulation on electric cables, these cells form a sheath around the nerve fibres in the peripheral nervous system which connect nerve cells to muscle cells and the surrounding area and conduct impulses. If this protective layer, known as the myelin sheath, is damaged, the exchange of information becomes slower, incorrect, or ceases entirely. Nerve fibres and the corresponding nerve cells may die completely, as the Schwann cells also provide them with nutrients. The consequences for patients are pain, numbness, muscular atrophy or problems with moving hands and feet correctly.

Improved understanding of networks

Researchers Dr. Fröb and Prof. Wegner, Chair of Biochemistry and Pathobiochemistry at FAU, hope that they will one day be able to help people suffering from diseases such as diabetic neuropathy, Charcot-Marie-Tooth disease or Guillain-Barré syndrome. However, there is still a long way to go. After more than 25 years of research on this type of cell, most of the proteins and protein complexes which have a role to play in the development and maturation of Schwann cells have been identified. However, the proteins interact with each other as well. Research into how the various components within this regulatory network interact is only just beginning. 'We will only be able to consider possible therapies once we have gained a better understanding of the networks,' Prof. Dr. Michael Wegner explains the current state of research.

The FAU working group has now succeeded in deciphering one of these complex links. Research has focused on a protein named Ep400, which the team has only recently discovered in Schwann cells. Together with other proteins, this protein acts within Schwann cells to ensure that DNA is packaged correctly and marked accordingly. Packaging is immensely important in order to transport genetic information to the cell nucleus as compactly as possible. Marking allows the required information to be found and read. In their experiments, the scientists deleted the protein from the Schwann cells. Thereafter, the mechanism for creating cells did not complete correctly and overlapped the maturation mechanism which would normally follow, meaning that certain proteins which were no longer required continued to be created without restriction, whilst other proteins which were required were no longer produced in sufficient quantities. As a result, the myelin sheaths of the Schwann cells were deformed. They were too thin and short, and the protective sheath of the nerve fibres was defective as a result. When the scientists deleted a further protein named Tfap2a which is normally regulated by Ep400 and which had been continued to be produced, there was a marked reduction in defects.

"We are, of course, pleased that we have made such a significant step forward in understanding the complex interdependencies within the Schwann cells," explains Prof. Wegner. "Our results indicate that DNA structural changes induced by proteins such as Ep400 are extremely important and may also be useful in future to develop therapies for peripheral neuropathy."

Franziska Fröb, Elisabeth Sock, Ernst R Tamm, Anna-Lena Saur, Simone Hillgärtner, Trevor J Williams, Toshihiro Fujii, Rikiro Fukunaga, Michael Wegner.
Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.
Nature Communicationsvolume 10, Article number: 2361 (2019). doi: 10.1038/s41467-019-10287-w.

Most Popular Now

73,000 Scientists collaborate over new COVID-19 Da…

More than 73,000 users collaborate on new online platform set up by the European Open Science Cloud Initiative, where scientists share COVID-19 data and accelerate our un...

Antiviral used to treat cat coronavirus also works…

Researchers at the University of Alberta are preparing to launch clinical trials of a drug used to cure a deadly disease caused by a coronavirus in cats that they expect ...

Roche and Regeneron collaborate to significantly i…

Roche (SIX: RO, ROG; OTCQX: RHHBY) and Regeneron (NASDAQ: REGN) announced are joining forces in the fight against COVID-19 to develop, manufacture and distribute REGN-COV...

Search for COVID-19 drugs boosted by SARS discover…

An extensive search and testing of current drugs and drug-like compounds has revealed compounds previously developed to fight SARS might also work against COVID-19. Us...

Pfizer and BioNTech share positive early data on l…

Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) shared additional Phase 1 safety and immunogenicity data from their ongoing U.S. study of the BNT162 mRNA-based vac...

Phase I clinical trial initiated for monoclonal an…

The first participants have been dosed in a Phase I trial of AZD7442, a combination of two monoclonal antibodies (mAbs) in development for the prevention and treatment of...

Europe's largest initiative launches to accelerate…

CARE (Corona Accelerated R&D in Europe) a new consortium supported by the Innovative Medicines Initiative (IMI) public-private partnership announced its launch to acceler...

Vitamin D deficiency may raise risk of getting COV…

In a retrospective study of patients tested for COVID-19, researchers at the University of Chicago Medicine found an association between vitamin D deficiency and the like...

Blocking cellular communication stops SARS-CoV-2

In the transmission of signals within the cell which, for example, stimulate cell growth or trigger metabolic processes, phosphate groups play an important biochemical ro...

Improving FDA's COVID-19 vaccine authorization and…

On March 28, the Food and Drug Administration (FDA) exercised its Emergency Use Authorization (EUA) authority to allow the use of hydroxychloroquine for the treatment of ...

Steroid found to improve survival of critically il…

A new international study published today has shown that treating critically ill patients with COVID-19 with the steroid hydrocortisone improves their chances of recovery...

Bayer and Informed Data Systems Inc. (One Drop) jo…

Bayer and Informed Data Systems Inc. (One Drop), a US-based digital health company, today announced that they have entered into an agreement to jointly develop digital he...