New FP7 eHealth Project - preDiCT

The preDiCT project officially launched 1 June 2008, with a mission to model, simulate, and ultimately predict the impact of pharmacological compounds on the heart's rhythm using computer models. This will require advances beyond the current state-of-the-art in:
  • Mathematical models of individual ion channels, which control how and when cells contract;
  • Tissue models, which encapsulate chemical processes and physical relationships at millions of separate points in the heart; and
  • The computer code, which must compute these relationships as a series of complex equations, to enable faster-than-real-time simulation of a beating heart.

Current best practice in pharmaceutical development relies on the Q-T interval (the spacing of two points on an electrocardiogram) as a proxy for potential danger. However, it is known that some drugs which fail this test do not lead to arrhythmia (e.g. Ranolazine, whose safety was demonstrated by the Oxford team). We hope to be able to develop more accurate gauges of potential cariotoxicity.

About 40% of drug candidates fail to come to market due to adverse impact on heart rhythm. preDiCT project hope to achieve better understanding of the underlying mechanisms, which may lead to refinement of the drug development process to avoid these side effects.

By extending the frontiers of "in silico" experimentation, the proposed project will enable future researchers to refine, replace and ultimately reduce the use of animals in pharmaceutical and other cardiac research.

The preDiCT project is embedded in the broader VPH initiative, with direct links to two other FP7-funded VPH projects: The Integrating Project euHeart, which will focus on patient-specific simulation for treatment of cardiovascular disease (17 partners, jointly coordinated by the Philips Technology Research Laboratory and the University of Oxford) and the Virtual Physiological Human Network of Excellence, a service to the community of VPH researchers (13 core partners plus broader membership, jointly coordinated by University College London and the University of Oxford).

The preDiCT project partners are:

  • F. Hoffmann-La Roche AG
  • Szegedi Tudományegyetem
  • Fujitsu Laboratories of Europe Limited
  • Glaxo Smithkline Research and Development
  • Universidad Politécnica de Valencia
  • Centro di Ricerca, Sviluppo e Studi Superiori in Sardegna
  • Novartis Pharma AG
  • Aureus Pharma SA

For further information, please visit:

Most Popular Now

Johnson & Johnson Announces Submission to Worl…

Johnson & Johnson (NYSE: JNJ) (the Company) announced that Janssen-Cilag International N.V. has submitted for Emergency Use Listing (EUL) to the World Health Organization...

Anticancer drug may improve outcome for severe COV…

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China ...

Pfizer and BioNTech commence global clinical trial…

Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) announced today that the first participants have been dosed in a global Phase 2/3 study to further evaluate the saf...

GSK and Vir Biotechnology expand coronavirus colla…

GlaxoSmithKline plc (LSE/NYSE: GSK) and Vir Biotechnology, Inc. (Nasdaq: VIR) have signed a binding agreement to expand their existing collaboration to include the resear...

Sanofi to provide manufacturing support to Johnson…

Sanofi has entered into an agreement with Janssen Pharmaceutical NV and Janssen Pharmaceuticals, Inc., two of the Janssen Pharmaceutical Companies of Johnson & Johnson, u...

One dose of COVID-19 vaccine provokes strong immun…

Although clinical trial data are encouraging, real-world evidence with regard to the COVID-19 vaccine remains scarce. In particular, response to the vaccine among those p...

Could a nasal spray prevent coronavirus transmissi…

A nasal antiviral created by researchers at Columbia University Vagelos College of Physicians and Surgeons blocked transmission of SARS-CoV-2 in ferrets, suggesting the n...

European Commission purchases additional 150 milli…

Moderna, Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced that the European Commission purchased an...

Sanofi and GSK initiate new Phase 2 study of their…

Sanofi and GlaxoSmithKline (GSK) announced the initiation of a new Phase 2 study with 720 volunteers aged 18 and over to select the most appropriate antigen dosage for Ph...

CureVac initiates rolling submission with European…

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), today annou...

Neandertal gene variants both increase and decreas…

Last year, researchers at Karolinska Institutet in Sweden and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany showed that a major genetic risk ...

Pfizer and BioNTech publish data from in vitro stu…

Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced the publication in Nature Medicine of data from in vitro studies that demonstrate that sera from in...