"These results were disappointing, given the trend towards prolonged survival seen in a Phase II study of axitinib in this extremely difficult-to-treat patient population," said Mace L. Rothenberg, M.D., senior vice president, clinical development and medical affairs, Pfizer's Oncology Business Unit. "However, we remain steadfastly committed to continued investigation of axitinib in renal cell carcinoma where it is currently in Phase III for 2nd line treatment."

The Company has notified all clinical trial investigators involved in the study and regulatory agencies of these interim findings and recommends patients discontinue treatment with axitinib. Pfizer encourages investigators to determine the best course of action for their patients. The full data set from this study is being analyzed and more details will be presented at an upcoming medical meeting.

Pancreatic cancer is the fourth leading cause of cancer deaths in the United States. In the past 20 years, there have been only 2 widely approved treatments, with many other drugs failing in Phase III trials.

"We have a robust pipeline of compounds in clinical development and will determine if one or more of those compounds can move forward in pancreatic cancer," said Dr. Rothenberg. "We also are continuing to evaluate axitinib in Phase II trials in other tumor types, including advanced non-small cell lung cancer and colorectal cancer."

Axitinib is an oral and selective inhibitor of VEGF receptors 1, 2 and 3. Axitinib is an investigational agent and has not yet been approved by the U.S. Food and Drug Administration or other global regulatory agencies.

For more information on Pfizer Oncology please visit http://www.pfizer.com.