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Researchers develop potent CDK9 inhibitor to overcome drug resistance in hematological malignancies

A research team led by Prof. LIU Qingsong and Prof. LIU Jing from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has recently developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant mutant form, offering a promising strategy for treating hematological malignancies.

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Research opens up new avenue for tuberculosis drug discovery

A new study by University of Bath scientists has highlighted two new potential families of drug molecules that could open the door to new treatments for tuberculosis.

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is the second largest infectious killer globally after COVID-19 and causes 1.3 million deaths annually.

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Aggressive skin cancer driven by mitochondrial processes - existing drugs offer promising treatment path

A new study led by researchers at Lund University in Sweden, reveals that melanoma, the deadliest form of skin cancer, can in some cases be driven by mitochondrial processes, which can be effectively targeted using existing drugs. In preclinical laboratory experiments with melanoma cell cultures, researchers successfully eliminated cancer cells by using antibiotics and inhibitors of mitochondrial energy production, highlighting a potential therapeutic breakthrough.

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Study highlights major hurdles for multinational clinical trials in Europe

A new study by investigators from Europe, including the Netherlands and the United Kingdom (UK), has shed light on significant ethical, administrative, regulatory, and logistical (EARL) hurdles in delivering multinational randomized clinical trials. The research was the first to comprehensively quantify these barriers for an international platform trial and emphasizes the need for urgent improvements, particularly in preparing for future public health crises.

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New model to find treatments for an aggressive blood cancer

Researchers working on an incurable blood cancer can now use a new lab model which could make testing potential new treatments and diagnostics easier and quicker, new research has found.

In a paper published in Nature Communications a team of researchers led from the University of Birmingham have studied blood cells from patients with a blood cancer called myelodysplastic syndrome disease (MDS).

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Researchers identify new protein target to control chronic inflammation

Chronic inflammation occurs when the immune system is stuck in attack-mode, sending cell after cell to defend and repair the body for months or even years. Diseases associated with chronic inflammation, like arthritis or cancer or autoimmune disorders, weigh heavily on human health - and experts anticipate their incidence is on the rise. A new study by investigators from Mass General Brigham identified a protein called WSTF that could be targeted to block chronic inflammation.

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Gene therapy restored hearing in deaf patients

Gene therapy can improve hearing in children and adults with congenital deafness or severe hearing impairment, a new study involving researchers at Karolinska Institutet reports. Hearing improved in all ten patients, and the treatment was well-tolerated. The study was conducted in collaboration with hospitals and universities in China and is published in the journal Nature Medicine.

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New study shows omega-6 does not increase inflammation

A new study published in Nutrients offers new insight into omega-6 and whether it is truly the proinflammatory fatty acid many claim it to be.

There is currently a heightened interest in the health effects of seed oils, many of which are rich in linoleic acid (LA), an essential omega-6 fatty acid.

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Study projects over 14 million preventable deaths by 2030 if USAID defunding continues

A new study published in The Lancet has raised urgent concerns about the global health consequences of recent cuts to U.S. foreign aid. The study, coordinated by researchers from the Barcelona Institute for Global Health (ISGlobal), together with the Institute of Collective Health of the Federal University of Bahia (ISC-UFBA), the University of California Los Angeles (UCLA), and the Manhiça Centre for Health Research (CISM), among others, estimates that 91 million deaths were prevented between 2001 and 2021 in low- and middle-income countries (LMICs)

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The most effective diabetes drugs don't reach enough patients yet

A UCSF analysis has found that the newer generation of much more effective diabetes medications are reaching only a fraction of the patients who are recommended to take them based on new guidelines.

Type 2 diabetes (T2D), a condition in which the body can't use insulin to clear sugar from the bloodstream, affects 1 in 10 Americans. It comes with grave health risks, including cardiovascular and kidney disease.

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