Harvard Medical School Faculty Advances Drug Safety Research with IBM Business Analytics

IBM (NYSE: IBM) announced that faculty from Harvard Medical School and Brigham & Women's Hospital will use IBM business analytics technology at the core of new research that examines the effectiveness of prescription drugs and spots potential safety issues.

Harvard Medical research teams are conducting advanced pharmacoepidemiology studies that look at the effects of drugs in large numbers of people based on insurance claims data. Using an IBM Netezza data warehouse appliance, the research teams will expand its studies to analyze data from millions of de-identified patient records with the aim to develop new data-intensive drug safety research methods.

Pharmacoepidemiology research is designed to answer important questions such as which anti-inflammatory drugs carry a risk of heart attack, what osteoporosis medications are most often used with good results, or how cost-effective are some drugs in treating mental health disorders.

"We wanted a computing platform with massive analytics power, but was extremely simple to administer," said Dr. Sebastian Schneeweiss, Associate Professor of Medicine, Harvard Medical School and Vice Chief of the Brigham & Women's Hospital Division of Pharmacoepidemiology and Pharmacoeconomics. "As global healthcare evolves toward a learning healthcare system with a need for ongoing comparative effectiveness and safety research integrated in routine care, it is imperative that research methods evolve in parallel. IBM Netezza will accelerate our ability to devise, test and publish new computationally intensive algorithms applied to ever larger longitudinal healthcare databases that we hope will become the gold standard for researchers globally."

Dr. Schneeweiss is the principal investigator of the AHRQ-funded DEcIDE Methods Center and Co-Chair of the Methods Core of the FDA-funded Mini Sentinel project. The study of patterns of health and illness associated with prescription drugs over long periods of time help determine which treatments are proven to have the best outcomes, and which are most viable for specific populations of patients. IBM Netezza business analytics technology will help Dr. Schnieeweiss' research team establish newer and more sophisticated analytic algorithms that can be automated to produce more accurate results.

"Our research lab is focused on the best ways to automate the continuous evaluation of the safety of medications, and we require fast systems to assemble and analyze data,” said Dr. Jeremy Rassen, Assistant Professor of Medicine at Harvard Medical School. “IBM Netezza puts us ahead of the curve, including capabilities for parallelized in-database analytics. We have already seen orders of magnitude performance improvement, without the use of any database administrator time, and system maintenance is done by our researchers and analysts."

Another area of research for Harvard Medical will be health economics and outcomes research (HEOR). Once the effectiveness of medications is established, pharmaceutical companies and health insurers have teams of HEOR analysts to demonstrate the value of new medical products for pricing and coverage decisions to provide higher quality of care. Intelligently mining claims data with a powerful analytics platform like IBM Netezza is often the best and fastest way to answer questions about the most effective therapies.

"The ability to glean insight and act on the analysis of massive amounts of claims data will help Harvard Medical School extend its reputation as one of the largest and most respected medical research organizations in the world," said Arvind Krishna, general manager, IBM Information Management.

About IBM
For information about IBM Netezza, please visit: www.netezza.com

For Information on IBM Information Management, please visit: http://www.ibm.com/software/data/information-on-demand/

Most Popular Now

Therapy using dual immune system cells effectively…

A newly developed immunotherapy that simultaneously uses modified immune-fighting cells to home in on and attack two antigens, or foreign substances, on cancer cells was ...

How to develop new drugs based on merged datasets

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions. In a recent paper, researchers at GlaxoSmithKline (GS...

New drug combination effective against SARS-CoV-2 …

More countries with greater resources are opening up for a more normal life. But COVID-19 and the SARS-CoV-2 virus are still a significant threat in large parts of the wo...

Cleveland Clinic study suggests steroid nasal spra…

A recent Cleveland Clinic study found that patients who regularly use steroid nasal sprays are less likely to develop severe COVID-19-related disease, including a 20 to 2...

Sanofi to focus its COVID-19 development efforts o…

Recent positive interim results of Sanofi's mRNA-based COVID-19 vaccine candidate Phase 1/2 study confirm the company's platform robust capabilities and strategy in mRNA...

Discovery of mechanics of drug targets for COVID-1…

A team of international researchers, including McGill Professor Stéphane Laporte, have discovered the working mechanism of potential drug targets for various diseases suc...

Phase II/III trial shows Ronapreve™ (casirivimab a…

Roche (SIX: RO, ROG; OTCQX: RHHBY) today confirmed positive data from the phase II/III 2066 study, investigating Ronapreve™ (casirivimab and imdevimab) in patients hospit...

Pfizer and BioNTech receive first U.S. FDA Emergen…

Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) announced that the U.S. Food and Drug Administration (FDA) has authorized for emergency use a booster dose of the P...

AZD7442 request for Emergency Use Authorization fo…

AstraZeneca has submitted a request to the US Food and Drug Administration (FDA) for an Emergency Use Authorization (EUA) for AZD7442, its long-acting antibody (LAAB) com...

Pfizer and BioNTech receive CHMP positive opinion …

Pfizer Inc. (NYSE: PFE, "Pfizer") and BioNTech SE (Nasdaq: BNTX, "BioNTech") today announced that the Committee for Medicinal Products for Human Use (CHMP) of the Europea...

Boehringer Ingelheim acquires Abexxa Biologics to …

Boehringer Ingelheim announced the acquisition of Abexxa Biologics Inc., a biopharmaceutical company taking a new approach in the fields of immuno-oncology and oncology r...

GSK welcomes WHO recommendation for broad roll-out…

GlaxoSmithKline (GSK) plc welcomes and applauds the WHO recommendation for the broader deployment of GSK's RTS,S malaria vaccine to reduce childhood illness and deaths fr...