Breaking WORLD PHARMA NEWS

Higher consumption of food preservatives is associated with an increased risk of type 2 diabetes

Higher consumption of food preservatives, widely used in industrially processed foods and beverages to extend their shelf life, has been linked to an increased risk of type 2 diabetes. These findings are the result of work carried out by researchers from Inserm, INRAE, Sorbonne Paris Nord University, Paris Cité University and Cnam, within the Nutritional Epidemiology Research Team (CRESS-EREN). They are based on health and dietary data from more than 100,000 adults participating in the NutriNet-Santé cohort study, and published in the journal Nature Communications.

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Blood test reveals risk of multimorbidity

Living with several chronic diseases at once, what is known as multimorbidity, is common among older people and puts a considerable strain on both the individual and the healthcare services. A collaborative study led by researchers at the Aging Research Center of Karolinska Institutet has now identified a small number of blood biomarkers that can predict the risk of multimorbidity. The study included over 2,200 individuals from the general Stockholm population, Sweden, above the age of 60.

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Bayer and Cradle enter collaboration to enhance AI-enabled antibody discovery and optimization

Bayer and Cradle have entered a three-year strategic collaboration to deploy Cradle’s scientific AI software platform for protein engineering. As part of the collaboration, Bayer will integrate the generative AI platform into existing R&D workflows to enhance lead generation and optimization across its therapeutic antibody pipeline.

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Inhalable therapy aims for one-two punch against advanced melanoma

Immune checkpoint molecules play a crucial role in keeping the immune system in balance and preventing an attack on the body's own cells. Cancer cells can use these checkpoints to hide from the immune system, making them a key focus for treatments that boost the immune response against cancer. Immune checkpoint inhibitors are proteins that release this brake on the immune system and unleash our immune cells to attack tumors.

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Machine learning drives drug repurposing for neuroblastoma

Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. The results from experimental trials showed slowing of tumour growth and higher survival rates.

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New technique lights up where drugs go in the body, cell by cell

When you take a drug, where in your body does it actually go? For most medications, scientists can make only educated guesses about the answer to this question. Traditional methods can measure the concentration of a drug in an organ like the liver, but they can’t pinpoint exactly which cells the drug binds to - or reveal unexpected places where the drug takes action.

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Right blood pressure drug can reduce healthcare costs

Patients who start their blood pressure treatment with ARB drugs continue with the same medicine to a greater extent than patients who start out with other drugs. Choosing the right drug from the outset can therefore improve both health and quality of life - as well as bringing down healthcare costs. This is shown in a new study based on data from 340,000 patients.

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The natural human protein drug may halt neuron death in Alzheimer's disease

Scientists at the University of Colorado Anschutz have discovered that while brain neuron changes, including cell loss, may begin in early life, a drug long-approved for other conditions might be repurposed to slow this damage, offering new hope for those with Alzheimer’s disease (AD) and other cognition issues.

The study was published in the journal Cell Reports Medicine.

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Groundbreaking discovery turns household plastic recycling into anti-cancer medication

A groundbreaking discovery led by the University of St Andrews has found a way to turn ordinary household plastic waste into the building block for anti-cancer drugs.

Household PET (polyethylene terephthalate) waste, such as plastic bottles and textiles, can be recycled in two main ways: mechanically or chemically.

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Accelerated cancer drug approvals deliver limited survival gains at high cost

Early access to new cancer drugs, granted accelerated approval by the U.S. Food and Drug Administration (FDA), has provided mixed benefits for patients while costing Medicare billions of dollars, reveals new research published in the journal BMJ Medicine.

Researchers found that between 2012 and 2020, 178,000 Medicare beneficiaries received early access to cancer drugs through the FDA’s accelerated approval pathway.

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