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Danish malaria vaccine passes test in humans

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Research
11 January 2019
For many years, a team of researchers at the University of Copenhagen have been focussing on developing a vaccine that can protect against the disease pregnancy malaria from which 220,000 people die every year. Now they have come a significant step closer to being able to introduce such a vaccine in the market. In a new study published in the scientific journal Clinical Infectious Diseases the vaccine has been subjected to so-called phase one clinical trial, and the results are uplifting:
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Stem cell study offers clues for optimizing bone marrow transplants and more

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Research
09 January 2019
Bone marrow transplants, which involve transplanting healthy blood stem cells, offer the best treatment for many types of cancers, blood disorders and immune diseases. Even though 22,000 of these procedures are performed each year in the US, much remains to be understood about how they work.
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Researchers uncover new mechanism of gene regulation involved in tumor progression

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Research
08 January 2019
Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.
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Stopping cancer from recruiting immune system double agents

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Research
04 January 2019
Cancerous tumors trick myeloid cells, an important part of the immune system, into perceiving them as a damaged part of the body; the tumors actually put myeloid cells to work helping them grow and metastasize (spread). A research team co-led by scientists at Rush University Medical Center have discovered a potential therapy that can disrupt this recruitment and abnormal function of myeloid cells in laboratory mice.
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Tumors backfire on chemotherapy

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Research
02 January 2019
Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the surgeon to remove. In those cases, the patients are very likely to remain cancer-free for life after surgery.
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Pediatric leukemia 'super drug' could be developed in the coming years

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Research
26 December 2018
Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development. When a key protein responsible for leukemia, MLL, is stabilized, it slows the progression of the leukemia, the most recent study found.
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Sutimlimab shows promise for hard-to-treat, rare blood disorder

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Research
17 December 2018
In a first-in-human clinical trial reported today in Blood, the investigational drug sutimlimab appeared to be effective in treating cold agglutinin disease, a rare chronic blood disorder for which there are currently no approved treatments. Cold agglutinin disease is caused by a malfunction in the immune system that causes antibodies - components of the immune system that are produced in the blood and help the body fight off disease - to mistakenly latch onto and kill red blood cells.
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More Pharma News ...

  1. First line immunotherapy combination fails to improve overall survival in lung cancer
  2. Helping the anti-parasitic medicine go down
  3. Scientists pave the way for saliva test for Alzheimer's disease
  4. Drug cocktail turns off the juice to cancer cells
  5. MIT engineers repurpose wasp venom as an antibiotic drug
  6. Statins overprescribed for primary prevention
  7. Cannabis-based compound may reduce seizures in children with epilepsy
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Business & Industry

  • Bayer exercised option to obtain full licensing rights for larotrectinib and BAY 2731954 (LOXO-195)
  • Boehringer Ingelheim (Canada) Ltd. and IBM Canada announce first of its kind collaboration to integrate blockchain technology into clinical trials
  • Merz delivers double-digit growth in strategic business areas
  • The Union for International Cancer Control and Pfizer announce new phase of global grants initiative supporting metastatic breast cancer patients
  • Merck to expand US biopharmaceutical R&D facility to advance innovative clinical pipeline

Research & Development

  • Researchers develop reversible antiplatelet therapy to fight clotting, cancer metastasis
  • How Viagra puts a brake on a master growth regulator to treat heart disease
  • Nano drops a million times smaller than a teardrop explodes 19th century theory
  • New insight into cell receptors opens the way for tailored cancer drugs
  • New pill can deliver insulin
  • Simple drug combination creates new neurons from neighboring cells
  • Cannabinoid compounds may inhibit growth of colon cancer cells

Conferences & Events

  • eyeforpharma Barcelona Conference, Expo & Awards 2019
  • SMi presents the 2nd Annual Conference: Injectable Drug Delivery 2019
  • 21st Annual Superbugs & Superdrugs Conference
  • SMi Group announces the 10th Annual RNA Therapeutics Conference
  • Pre-Filled Syringes & Injectable Drug Devices Europe 2018
  • Social Media in the Pharmaceutical Industry Conference 2019
  • Lyophilization USA Conference 2018

Regulatory Affairs

  • FDA takes new steps to adopt more modern technologies for improving the security of the drug supply chain
  • FDA takes action against 17 companies for illegally selling products claiming to treat Alzheimer's disease
  • FDA approves first therapy for the treatment of adult patients with a rare blood clotting disorder
  • FDA approves first generic Advair Diskus
  • FDA approves first treatment for rare blood disease
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