Research & Development News Channel

New 'systems genetics' study identifies possible target for epilepsy treatment

A single gene that coordinates a network of about 400 genes involved in epilepsy could be a target for new treatments, according to research. Epilepsy is a common and serious disease that affects around 50 million people worldwide. The mortality rate among people with epilepsy is two to three times higher than the general population.

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Long-term use of hormonal contraceptives is associated with an increased risk of brain tumors

Taking a hormonal contraceptive for at least five years is associated with a possible increase in a young woman's risk of developing a rare tumour, glioma of the brain. This project focussed on women aged 15-49 years and the findings are published in the British Journal of Clinical Pharmacology.

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Drinking moderate amounts of alcohol is linked to reduced risk of heart failure

Evidence already exists for the beneficial effects of drinking moderate amounts of alcohol on the risk of developing a number of heart conditions; however, the role it plays in the risk of developing heart failure has been under-researched with conflicting results. Now, a large study of nearly 15,000 men and women, published online in the European Heart Journal, shows that

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Vitamin D protects against colorectal cancer by boosting the immune system

A new study by Dana-Farber Cancer Institute investigators demonstrates that vitamin D can protect some people with colorectal cancer by perking up the immune system's vigilance against tumor cells. The research, published by the journal Gut, represents the first time that a link between vitamin D and the immune response to cancer has been shown in a large human population.

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Experts recommend weight loss drugs, surgery as supplement to lifestyle interventions

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on strategies for prescribing drugs to manage obesity and promote weight loss. The CPG, entitled "Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline," was published online and will appear in the February 2015 print issue of the Journal of Clinical Endocrinology and Metabolism (JCEM), a publication of the Endocrine Society.

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Scientists develop novel platform for treatment of breast, pancreatic cancer

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers. In the new study, to be published in the February 2015 print edition of the journal Molecular Pharmacology, the scientists showed that the compound, known as SR1848, reduces the activity and expression of the cancer-related protein called "liver receptor homolog-1" or LRH-1.

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Researchers dispute warning that drugs for high cholesterol could impair memory, cognitive function

Researchers question whether there is substance to the US Food and Drug Agency's recent warning that statins could affect the memory, attention span and other cognitive abilities of people who take this drug to control high cholesterol. This follows a systematic review of 25 clinical trials incorporating nearly 47,000 people.

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