A new HER2 mutation, a clinical trial and a promising diagnostic tool for metastatic breast cancer
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- Category: Research
There is a group of metastatic breast cancers that has the HER2 gene amplified - the cells have many copies of it - which leads to enhanced activity of the product enzyme, a tyrosine kinase. HER2 has been established as a therapeutic target in breast cancer, and breast cancers in which the HER2 gene is not amplified do not, in general, respond to HER2-directed therapeutic approaches.
New drug may treat and limit progression of Parkinson's disease
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- Category: Research
Researchers at Binghamton University have developed a new drug that may limit the progression of Parkinson's disease while providing better symptom relief to potentially hundreds of thousands of people with the disease. Symptoms of Parkinson's disease are commonly managed using a selective dopamine receptor agonists. While these drugs are useful in early-stage Parkinson's, they tend to lose efficacy in later disease stages.
Green tea ingredient may ameliorate memory impairment, brain insulin resistance, and obesity
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- Category: Research
A study published online in The FASEB Journal, involving mice, suggests that EGCG (epigallocatechin-3-gallate), the most abundant catechin and biologically active component in green tea, could alleviate high-fat and high-fructose (HFFD)-induced insulin resistance and cognitive impairment.
Drug combination shows better tolerance and effectiveness in metastatic renal cell cancer
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- Category: Research
A new cooperative research study including Norris Cotton Cancer Center's Lionel Lewis, MB BCh, MD, finds that nivolumab plus ipilimumab therapy demonstrated manageable safety, notable antitumor activity, and durable responses with promising long term overall survival in patients with metastatic renal cell cancer (mRCC).
Americans say discussions about clinical trials should be part of standard of care
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- Category: Development
An overwhelming majority of Americans (86%) agree that health care professionals should discuss clinical trials with patients diagnosed with a disease as part of their standard of care, according to a new national public opinion survey commissioned by Research!America. And three-quarters of respondents (75%) agree that taking part in clinical trials is as valuable to our health care system as giving blood. But Americans are split on whether it's important for everyone to take part in a clinical trial if they are asked - 44% agree while 45% disagree and 12% are not sure.
Antidepressant use in pregnant women linked to small increase in autism
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- Category: Research
A new study found that antidepressant medications taken during pregnancy may be linked to the development of autism in children - although the effect appears to be limited. In looking at a cohort of children born between 2001 and 2011 in Stockholm, Sweden, Drexel University's Brian Lee, PhD, and Craig Newschaffer, PhD, and their co-authors (including lead author Dheeraj Rai, PhD, of the University of Bristol) found that children born to mothers who had taken anti-depressants at any point during their pregnancy were 45 percent more likely to be diagnosed with autism.
How physical exercise prevents dementia
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- Category: Research
Numerous studies have shown that physical exercise seems beneficial in the prevention of cognitive impairment and dementia in old age. Now researchers at Goethe University Frankfurt have explored in one of the first studies worldwide how exercise affects brain metabolism. In order to further advance current state of knowledge on the positive influence of physical activity on the brain, gerontologists and sports physicians at Goethe University Frankfurt have examined the effects of regular exercise on brain metabolism and memory of
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