Novartis renews drug donation of Egaten® (triclabendazole) until 2022

NovartisNovartis reaffirms its commitment to the fight against liver fluke (fascioliasis), signing a renewed memorandum of understanding with the World Health Organization (WHO) to extend its drug donation for Egaten® (triclabendazole) until 2022. Egaten is currently the only treatment for fascioliasis recommended by the WHO and is on the WHO Model List of Essential Medicines.

This new four-year commitment (January 2019 to December 2022) includes the donation of 600,000 tablets of Egaten annually, expected to reach 300,000 patients per year. Since the start of the donation program in 2005, Novartis has donated approximately 4 million tablets of Egaten, valued at USD 41 million, helping to treat around 2 million people with fascioliasis in more than 30 countries worldwide.

Fascioliasis, commonly known as liver fluke infestation, is a neglected tropical disease that currently affects an estimated 2.4 million people worldwide[1], with an additional 180 million at risk of infection[2]. It is caused by two species of parasitic flatworms or trematodes that mainly affect the liver (Fasciola hepatica or Fasciola gigantica). Both species can infect humans following ingestion of larvae in contaminated water or food (mainly raw or undercooked vegetation). The larvae mature into adult worms in the biliary tract.

No continent is free from fascioliasis; human cases have been reported from more than 70 countries worldwide[1]. It is likely that where animal cases are reported, human cases also exist. Recognized areas of high transmission are the highlands of South America, the Nile valley, the Caspian sea basin, as well as east Asia and south-east Asia[3].

"This donation will help increase access to treatment in many countries, particularly in communities where cases are clustered and among children of school age who have both the highest prevalence and intensity of infection," said Antonio Montresor, M.D., Medical Officer, WHO Department of Control of Neglected Tropical Diseases.

Left untreated, fascioliasis can result in considerable pain and discomfort, leading to poor quality of life and loss of productivity. The acute phase of the disease is manifested with fever, abdominal pain, nausea, diarrhea and eosinophilia. The disease later progresses to a latent phase with less symptoms and ultimately into a chronic or obstructive phase. In children, fascioliasis can be a serious infection with high fever, enlarged tender liver, and anemia; in some cases deaths have been reported.

Egaten is a single-dose treatment for fascioliasis caused by Fasciola hepatica or Fasciola gigantica in patients 6 years of age or older. Novartis originally developed triclabendazole to treat fascioliasis in domestic livestock, and subsequently developed it for human use in partnership with the WHO.

"Novartis looks forward to its continued partnership with the WHO to reduce the burden of fascioliasis around the world through access to effective treatment," said Patrice Matchaba, M.D., Group Head of Global Health and Corporate Responsibility. "The extension of our donation through 2022 is a testament to our company's long-term commitment to reimagine the fight against neglected tropical diseases."

Novartis has a long-standing commitment to the research and development of medicines for neglected tropical diseases. The Novartis Institute for Tropical Diseases is dedicated to finding new medicines to treat neglected diseases. Research currently focuses on parasitic diseases such as malaria, cryptosporidiosis (diarrheal disease) and three major kinetoplastid diseases: human African trypanosomiasis (sleeping sickness), Chagas disease and leishmaniasis.

About Novartis

Novartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, cost-saving generic and biosimilar pharmaceuticals and eye care. Novartis has leading positions globally in each of these areas. In 2017, the Group achieved net sales of USD 49.1 billion, while R&D throughout the Group amounted to approximately USD 9.0 billion. Novartis Group companies employ approximately 125,000 full-time-equivalent associates. Novartis products are sold in approximately 155 countries around the world.

1. http://www.who.int/foodborne_trematode_infections/fascioliasis/en/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568335/
3. http://www.who.int/foodborne_trematode_infections/fascioliasis/fascioliasis_epidemiology/en/

Most Popular Now

Novartis receives FDA approval for Mayzent® (sipon…

Novartis today announced that the US Food and Drug Administration (FDA) has approved Mayzent® (siponimod) for the treatment of adults with relapsing forms of multiple scl...

Compound that kills drug-resistant fungi is isolat…

Antimicrobial and antifungal resistance, which describe the ability of bacteria and other pathogens to resist the effects of drugs to which they were once sensitive, is a...

First bacterial genome created entirely with a com…

All the genome sequences of organisms known throughout the world are stored in a database belonging to the National Center for Biotechnology Information in the United Sta...

Liver, colon cancer cells thwarted by compounds de…

The plant that adds flavor, color and bitterness to beer also produces a primary compound that thwarts cancer cells, and two important derivatives of the compound do as w...

Clinical trial finds therapy to be well-tolerated …

A phase I clinical trial that set out to assess the safety of a new combination therapy for a type of aggressive brain tumour has found the treatment to be well tolerated...

Immune cells fighting blood cancer visualized for …

When cancer escapes the immune system, our defenses are rendered powerless and are unable to fight against the disease. Chimeric antigen receptor T cells (CAR T cells) re...

FDA approves treatment for patients with a type of…

The U.S. Food and Drug Administration today approved Cimzia (certolizumab pegol) injection for treatment of adults with a certain type of inflammatory arthritis called no...

Boehringer Ingelheim announces FDA and EMA regulat…

Boehringer Ingelheim has filed for regulatory approval of nintedanib in patients with systemic sclerosis associated interstitial lung disease (SSc-ILD) with the FDA and E...

Selumetinib granted US Breakthrough Therapy Design…

AstraZeneca and MSD, Inc., Kenilworth, NJ, US (MSD: known as Merck & Co., Inc. inside the US and Canada) today announced that the US Food and Drug Administration (FDA) ha...

Novartis adds clinical and preclinical anti-inflam…

Novartis announced that it is adding to its broad portfolio of immunomodulatory medicines with the planned acquisition of IFM Tre, a subsidiary of IFM Therapeutics LLC fo...

Forxiga approved in Japan for type-1 diabetes

The Japanese Ministry of Health, Labour and Welfare (MHLW) has approved Forxiga (dapagliflozin) as an oral adjunct treatment to insulin for adults with type-1 diabetes (T...

Novartis continues transformation into a leading m…

Novartis today completed the spin-off of the Alcon eye care devices business through a dividend-in-kind distribution to holders of Novartis shares and ADRs (American Depo...