Sanofi-aventis and CureDM Sign Exclusive Worldwide License Agreement

sanofi-aventisSanofi-aventis (EURONEXT: SAN and NYSE: SNY) and CureDM Group Holdings, LLC, announced today a global license agreement on a novel human peptide, Pancreate™, which could restore a patients' ability to produce insulin and other pancreatic hormones in both type 1 and type 2 diabetes.

Pancreate™ is a bioactive peptide sequence of a naturally occurring human protein that has been shown in preclinical studies to stimulate the growth of new insulin producing islets in the pancreas, resulting in restoration of normal metabolic function and glucose control in the blood. The commencement of Phase I studies is planned for later this year.

Under the terms of this agreement, sanofi-aventis is granted an exclusive worldwide license to develop, manufacture and commercialize Pancreate™ and related compounds. CureDM will receive an upfront payment, as well as development, regulatory and commercial milestone payments. All such payments could reach a total of US$ 335 million. In addition, CureDM is eligible to receive tiered royalties on worldwide product sales.

"Sanofi-aventis is pleased to add to its Diabetes Division pipeline this highly innovative technology that has the potential to stimulate the formation of fully functional new pancreatic islets, thereby helping to restore patients' pancreatic function," explained Dr. Marc Cluzel, Executive Vice-President R&D, sanofi-aventis. "Once fully developed, Pancreate™ has the potential to become the first regenerative treatment of type 1 and type 2 diabetes and to address the challenges that the growing diabetes epidemic poses on patients and healthcare systems."

This new collaboration is another example of the company's strategic commitment to sustain its leadership in diabetes through new technologies. It further reinforces its ambition to become the leading diabetes company.

About Pancreate™
Pancreate™ (proisletide acetate) is a first-in-class human peptide (HIP-2B) sequence of a naturally occurring human protein that stimulates the formation of functional insulin producing neo-islets from pancreatic progenitor cells. In both type 1 and type 2 diabetes, a fundamental problem is too few insulin-producing islet structures to keep up with insulin demand. Islets are highly complex multicellular organelles that contain the insulin-producing beta cell and four other cells types, all of which play a role in maintaining glucose levels. In addition, islet structures provide the necessary metabolic control of insulin release that makes the pancreas able to keep a consistent glucose level in the blood. Therein, restoring whole islets is paramount correcting the erratic blood glucose fluctuations associated with diabetes, making Pancreate™ a fundamentally new approach to treat the disease.

About CureDM
CureDM is a biopharmaceutical company focused on the discovery and development of new therapies that prevent, ameliorate, or reverse diseases of metabolism. CureDM was co-founded by a molecular biologist and two clinical endocrinologists who experienced the unmet medical need in diabetes patients on a daily basis, which provided motivation for the discovery of Pancreate™. For more information about CureDM, visit www.curedm.com.

About sanofi-aventis
Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).

Source: Diabetes PubMed

Most Popular Now

GSK reaches agreement with Novartis to acquire ful…

GlaxoSmithKline plc (LSE/NYSE: GSK) today announces that it has reached an agreement with Novartis for the buyout of Novartis' 36.5% stake in their Consumer Healthcare Jo...

Canadian neuroscientists say daily ibuprofen can p…

A Vancouver-based research team led by Canada's most cited neuroscientist, Dr. Patrick McGeer, has successfully carried out studies suggesting that, if started early enou...

First proof a synthesized antibiotic is capable of…

A "game changing" new antibiotic which is capable of killing superbugs has been successfully synthesised and used to treat an infection for the first time - and could lea...

Merck partners with Medisafe to help improve medic…

Merck, a leading science and technology company, today announced a new collaboration with US-based Medisafe to help its cardiometabolic patients better manage medication ...

Phase III data in The Lancet show Novartis siponim…

Novartis today announced that the full results from the Phase III EXPAND study of oral, once-daily siponimod (BAF312) in secondary progressive multiple sclerosis (SPMS) w...

Taking a standard prostate cancer drug with food b…

By taking a high-cost drug with a low-fat meal - instead of on an empty stomach, as prescribed - prostate cancer patients could decrease their daily dose, prevent digesti...

New immunotherapy for lung cancer shows promise of…

In a groundbreaking development, results from a recent clinical trial to treat lung cancer show that a novel immunotherapy combination is surprisingly effective at contro...

Boehringer Ingelheim and OSE Immunotherapeutics an…

Boehringer Ingelheim and OSE Immunotherapeutics, a biotechnology company focused on the development of innovative immunotherapies, have announced a collaboration and excl...

Personalized tumor vaccine shows promise in pilot …

A new type of cancer vaccine has yielded promising results in an initial clinical trial conducted at the Perelman School of Medicine at the University of Pennsylvania and...

New targeted therapy schedule could keep melanoma …

Skin melanoma, a particularly insidious cancer, accounts for the vast majority skin cancer deaths and is one of the most common cancers in people under 30. Treatment for ...

Researchers identify chemical compound that inhibi…

An organic chemical compound shows effective antiviral activity against Ebola virus and several other viruses, according to a study led by Georgia State University. The r...

When drugs are wrong, skipped or make you sick: Th…

Rising drug prices have gotten a lot of attention lately, but the actual cost of prescription medications is more than just the dollars and cents on the bill. Researchers...