Antioxidants and lung cancer risk

An epidemiological study published in Frontiers in Oncology suggests that a diet high in carotenoids and vitamin C may protect against lung cancer. The study authors found that vitamin C appears to reduce the risk of lung cancer in heavy smokers while beta-carotene, alpha-carotene, beta-cryptoxanthin, and lycopene play the same role in male heavy smokers.

Some of these antioxidants were also associated with a lower lung cancer risk in female moderate smokers and nonsmokers. "Our results suggest that vitamin C protects against lung cancer in women who have never smoked, something that to our knowledge has not been reported previously," stated postgraduate fellow Martine Shareck, lead author of the study.

Data from a case-control study of lung cancer was used in the investigation, one of the few to examine the role of antioxidants like carotenoids and vitamin C by smoking intensity. It is the first study to consider both smoking duration and time since quitting, two key smoking history factors for lung cancer.

"For the three most common tumour subtypes, we observed that high intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, and vitamin C were associated with a reduced risk of squamous cell carcinoma, while high intakes of beta-carotene and alpha-carotene lowered the risk of adenocarcinoma," explained professor and study co-author Marie-Élise Parent of the INRS-Institut Armand-Frappier Research Centre. "Both medium and high intakes of beta-cryptoxanthin and lycopene reduced the risk of small cell carcinoma."

Cigarette smoking is the foremost risk factor for lung cancer, the leading cause of cancer mortality worldwide. Yet diet can influence the occurrence of this cancer. In light of the study results, the authors conclude it is desirable to promote consumption of fruits and vegetables rich in carotenoids and vitamin C to reduce lung cancer risk in nonsmokers and smokers, including heavy smokers.

Shareck M, Rousseau M-C, Koushik A, Siemiatycki J and Parent M-E.
Inverse Association between Dietary Intake of Selected Carotenoids and Vitamin C and Risk of Lung Cancer.
Front. Oncol. 7:23. doi: 10.3389/fonc.2017.00023.

Most Popular Now

In wine, there's health: Low levels of alcohol goo…

While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study, which appe...

Sanofi to acquire Ablynx for €3.9 Billion

Sanofi and Ablynx, a biopharmaceutical company engaged in the discovery and development of Nanobodies®, entered into a definitive agreement under which Sanofi will offer ...

Repurposed drug found to be effective against Zika…

In both cell cultures and mouse models, a drug used to treat Hepatitis C effectively protected and rescued neural cells infected by the Zika virus - and blocked transmiss...

Interim publications of randomized trials make new…

Early results from randomized trials are sometimes published before the trial is completed. The results of such interim publications may generate a great deal of interest...

More stroke patients may receive crucial treatment…

More patients could be eligible for critical treatments to remove or dissolve blood clots that cause strokes, according to a new treatment guideline issued by the America...

Drug trial protocol redactions by industry sponsor…

New research published by the Journal of the Royal Society of Medicine exposes the extent of redactions in protocols for industry-sponsored randomised drug trials. Trial ...

Advanced Accelerator Applications receives FDA ap…

Novartis AG (NYSE: NVS) announced that Advanced Accelerator Applications, a subsidiary of Novartis Groupe S.A., has received US Food and Drug Administration (FDA) approva...

Blood vessel-on-a-chips show anti-cancer drug effe…

Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel ...

Guidelines extended to improve the use of feedback…

Researchers have recommended changes to international guidelines used in the development of clinical trials in an effort to gain information about the impact of the treat...

Roche reports good results in 2017

In 2017, Group sales rose 5% to CHF 53.3 billion. Core operating profit grew 3% and Core EPS increased 5%, reflecting the good underlying business performance. On an IFRS...

Brilinta significantly reduces CV events and coron…

AstraZeneca today announced results from a new sub-analysis of the Phase III PEGASUS-TIMI 54 trial, demonstrating a risk reduction of 19% in MACE (the composite of CV dea...

FDA approves new treatment for certain digestive t…

The U.S. Food and Drug Administration today approved Lutathera (lutetium Lu 177 dotatate) for the treatment of a type of cancer that affects the pancreas or gastrointesti...

Pharmaceutical Companies

[ A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Z ]